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SmartSerialMail is an email marketing software that lets you create newsletters, personalized emails, and send out bulk mailings. You can import recipient lists from various sources such as MS Excel, Outlook, or your own customer database and define any number of distribution lists.
Mozilla Thunderbird is an open source email client that simplifies the process of checking your emails. Once configured using your ID and password, simply launch Thunderbird to download, reply-to, and send emails. You can also use this application for chatting on your Google Talk, IRC, Twitter, XMPP, and Yahoo accounts.